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KMID : 0363819950290030294
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Korean Journal of Nuclear Medicine
1995 Volume.29 No. 3 p.294 ~ p.306
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Effect of NMDA Receptor Antagonist on Local Cerebral Glucose Metabolic Rate in Focal Cerebral Ischemia.
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김상은
홍승봉/윤병우/배상균/최창운/이동수/정준기/노재규/이명철
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Abstract
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There has recently been increasing interest in the use of NMDA receptor antagonists as potential neuroprotective agents for the treatment of ischemic stroke. To evaluate the neuroprotective effect of the selective non-competitive NMDA receptor
antagonist MK-801 in focal cerbral ischemia, local cerebral glucose utilization (ICGU) was examined in 15 neuroanatomically discrete regions of the conscious rat brain using the 2-deoxy-D[14C] glucose quantitative autoradiographic technique 24 hr
after
left middle cerebral artery occlusion (MCAO). Animals received MK-801(5 mg/kg i.v.) or saline vehicle before (20-30min) or after (30 min) MCAO. Both pretreatment and posttreatment of MK-801 increased occluded/non-occluded ICGU ration in 7 and 5
of
the
15 regions measured, respectively (most notably in cortical structures). Following MK-801 pretreatment, there was evidence of widespread increases in ICGU not only in the non-occluded hemisphere (12 of the 15 areas studied) but also in the
occluded
hemisphere (13 of the 15 areas studied), while MK-801 postreatment did not significantly increase ICGU both in the normal and occluded hemispheres. These data indicate that MK-801 has a neuroprotective effect in focal cerebral ischemia and
demonstrate
that MK-801 provides widespread alterations of glucose utilization in conscious animals.
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KEYWORD
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